O2 Academy Bristol is a renowned music venue and nightclub located in the heart of Bristol, United Kingdom. The venue originally opened in 1966 as the Mecca Ballroom, quickly gaining a reputation as a vibrant social hub for live music, dancing, and entertainment. Over the decades, the building transitioned through various names and purposes, including the Bristol Academy and Carling Academy, before becoming part of the UK-wide O2 Academy group in 2009 following a sponsorship deal with the telecommunications company O2.

The venue is housed in a notable Art Deco building on Frogmore Street, maintaining many original architectural features, which adds to its distinctive character and charm. With a main auditorium capacity of around 1,600, the O2 Academy offers an intimate yet dynamic atmosphere, making it popular for both up-and-coming acts and internationally acclaimed performers. Throughout its history, O2 Academy Bristol has cemented itself as a cornerstone of the city's rich musical culture, regularly hosting club nights, live concerts, and special events.

It is celebrated not only for its excellent acoustics and central location but also for its ability to attract a diverse range of talent and audiences. The venue has played a significant role in supporting the local music scene, providing a platform for Bristolian artists to perform alongside established names. Despite minor refurbishments and updates to its facilities over the years, the structure has remained in its original location and continues to be a focal point for nightlife and live entertainment in Bristol.

Its cultural significance is reflected in the loyalty of its patrons and its reputation as an essential tour stop for artists across genres. Notable artists who have graced the stage at O2 Academy Bristol include international acts such as Arctic Monkeys, Ed Sheeran, Amy Winehouse, Coldplay, Muse, Oasis, The Killers, Florence + The Machine, and Queens of the Stone Age. In addition, local talent and Bristol-born artists like Massive Attack, Roni Size, and Idles have also performed at the venue, highlighting its importance as both an incubator for local scenes and a prestigious stop on worldwide tours.